In collaboration with the groups of Dr. Gilad Barnea at Brown University and Dr. Yoshi Aso at Janelia Research Campus, Dr. Kristin Scaplen et al used transTango to map postsynaptic connections to mushroom body output neurons in her new work entitled "Transsynaptic mapping of mushroom body output neurons", just published in eLife. She identified anatomically and functionally a multi-layer circuit that includes GABAergic and cholinergic neurons converging onto the same subset of neurons in the fan-shaped body and lateral accessory lobe. This circuit architecture allows for a fast update of the online processing of sensory information before executing behavior, and is likely a conserved motif among insects. This work provides insight into general circuit principles for how information is processed to form memories and update them in complex brains.
New collaborative work with the Barnea lab, led by Dr. Kristin Scaplen published!
Updated: Jan 30, 2022